Discussion about this post

User's avatar
Dirk Dunning's avatar

It is even worse than you may realize.

Autoimmune:

The degree of harm grows with each infection. These include a 13-14% risk of a new autoimmune disease with each infection. That is risk for an individual - impact for populations and society. Then add a similar 13-14% 'risk' of reactivating or exacerbating previously developed autoimmune diseases. Anyone with long standing autoimmune disease, likely has 6 or 7 autoimmune diseases in a complex, not just one. This means a near certainty of active autoimmune disease following every infection for those who already have such diseases. Each is disabling.

Immune destruction:

Each infection carries a serious level of damage to the adaptive immune system. Inside of 3 or 4 infections, a syndrome indistinguishable from AIDS may develop with even worse consequences in loss of adequate immune response to other diseases. As a consequence, diseases that were a nuisance, become dangerous or lethal.

Accelerated Aging:

Through at least three different mechanisms (organ and brain injury; methylation of the epi-genome; and truncation of the telomeres), each infection adds to the existing age. The biological age rapidly diverges from the chronological age. Each infection costs about 10 years equivalent of aging from damage to organs and brain. Each infection adds about 7 years in aging from methylation of the epi-genome. Each infection adds age dependent aging from truncation of the telomeres roughly equal to 35 years for new borns. 27 years for 20 year olds. 18 years for 40 year olds,10 years for 60 year olds - as assessed based on their biological age at infection, not their calendar age.

As a result, a new born infected three times one year apart is likely biologically something approaching 69 years age, Though it no doubt takes time for that to reflect in biological impacts.

Then there is the accumulating impact of clotting defects from damage to the complimentary immune system and long-COVID with immense impacts to every system of the body.

The point here being that much of this harm happens and cannot be undone by the time a second infection has occurred. The lag from the infection and recovery from those infections combined with the annual or twice annual rate of infection for most people, and the complete lack of efforts to inform the public or control the spread, and that we are now entering the fifth year of the pandemic mean that we are only now beginning to see the impacts accumulated from two years ago. These will no doubt rise dramatically over the next year and the years to follow.

The result will be catastrophic to society. By ten years, most of those who chose not to seriously protect themselves may be gone.

Then there are the things we don't know or aren't certain about. It is now fairly certain that SARS-CoV-2 increases the rates of cancer. Add that to the immune system damage and the results are not pretty.

Expand full comment
alan2102's avatar

"our relative privilege as citizens of the imperial core could only ever last so long."

Correct. And it is coming to an end right now. Covid or no covid, doesn't matter. Though

covid will no doubt accelerate what was already inevitable.

Expand full comment
14 more comments...

No posts